https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 The role of the retinoids in schizophrenia: genomic and clinical perspectives https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:40464 Wed 27 Jul 2022 13:10:26 AEST ]]> Pairwise common variant meta-analyses of schizophrenia with other psychiatric disorders reveals shared and distinct gene and gene-set associations https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:45203 0.05). Multivariable gene-set association suggested that common variation enrichment within biologically constrained genes observed for schizophrenia also occurs across several psychiatric phenotypes. Pairwise meta-analysis of schizophrenia and each psychiatric phenotype was implemented and identified 330 significantly associated genes (PMeta < 2.7 × 10−6) that were only nominally associated with each disorder individually (P < 0.05). These analyses consolidate the overlap between the genomic architecture of schizophrenia and other psychiatric disorders, uncovering several candidate pleiotropic genes which warrant further investigation.]]> Wed 26 Oct 2022 14:40:02 AEDT ]]> The genetic architecture of the human cerebral cortex https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:42676 Wed 22 Mar 2023 14:34:07 AEDT ]]> Cell type-specific manifestations of cortical thickness heterogeneity in schizophrenia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:47091 Wed 14 Dec 2022 09:37:26 AEDT ]]> Advancing the use of genome-wide association studies for drug repurposing https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46016 Wed 09 Nov 2022 08:31:02 AEDT ]]> Alteration of DNA Methylation and Epigenetic Scores Associated with Features of Schizophrenia and Common Variant Genetic Risk https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55024 Wed 03 Apr 2024 15:41:54 AEDT ]]> The maternal immune activation model uncovers a role for the Arx gene in GABAergic dysfunction in schizophrenia https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44959 Arx gene, critical to healthy neurodevelopment of PV interneurons, is reduced in the forebrain of MIA exposed mice. Finally, in a whole-genome sequenced patient cohort, we identified a novel missense mutation of ARX in a patient with schizophrenia and in the Psychiatric Genomics Consortium 2 cohort, a nominal association of proximal ARX SNPs with the disorder. This suggests MIA, as a risk factor for schizophrenia, may be influencing Arx expression to induce the GABAergic dysfunction seen in schizophrenia and that the ARX gene may play a role in the prenatal origins of schizophrenia pathophysiology.]]> Tue 25 Oct 2022 12:28:24 AEDT ]]> miRNA cargo in circulating vesicles from neurons is altered in individuals with schizophrenia and associated with severe disease https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:54330 Tue 20 Feb 2024 15:58:57 AEDT ]]> Variation in cardiovascular disease risk factors among older adults in the Hunter Community Study cohort: A comparison of diet quality versus polygenic risk score https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50122 Tue 11 Jul 2023 15:09:52 AEST ]]> MicroRNA binding site variation is enriched in psychiatric disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50575 Tue 01 Aug 2023 09:52:01 AEST ]]> Investigation of glycaemic traits in psychiatric disorders using Mendelian randomisation revealed a causal relationship with anorexia nervosa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:49464 Thu 18 May 2023 14:19:57 AEST ]]> Pharmacological enrichment of polygenic risk for precision medicine in complex disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:41990 Thu 10 Aug 2023 12:12:50 AEST ]]> Wnt receptor gene FZD1 was associated with schizophrenia in genome-wide SNP analysis of the Australian Schizophrenia Research Bank cohort https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:44131 Sat 08 Oct 2022 12:36:32 AEDT ]]> Linking Polygenic Risk of Schizophrenia to Variation in Magnetic Resonance Imaging Brain Measures: A Comprehensive Systematic Review https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53905 Mon 22 Jan 2024 15:11:18 AEDT ]]> The MIR137 VNTR rs58335419 Is Associated with Cognitive Impairment in Schizophrenia and Altered Cortical Morphology https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:46407 n = 299) and healthy controls (n = 131), we observed that the MIR137 4-repeats VNTR (VNTR₄) variant was enriched in a cognitive deficit subtype of schizophrenia and associated with altered brain morphology, including thicker left inferior temporal gyrus and deeper right postcentral sulcus. These findings suggest that the MIR137 VNTR₄ may impact neuroanatomical development that may, in turn, influence the expression of more severe cognitive symptoms in patients with schizophrenia.]]> Mon 21 Nov 2022 11:38:46 AEDT ]]> Evidence of genetic overlap and causal relationships between blood-based biochemical traits and human cortical anatomy https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50979 Mon 14 Aug 2023 15:25:32 AEST ]]> Genetics-informed precision treatment formulation in schizophrenia and bipolar disorder https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50980 Mon 14 Aug 2023 15:24:38 AEST ]]> Pairwise genetic meta-analyses between schizophrenia and substance dependence phenotypes reveals novel association signals with pharmacological significance https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:50935 Mon 14 Aug 2023 12:29:31 AEST ]]> Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:55070 Mon 08 Apr 2024 13:27:57 AEST ]]> Polygenic disruption of retinoid signalling in schizophrenia and a severe cognitive deficit subtype https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:48305 Mon 01 May 2023 15:23:00 AEST ]]> Multiomic prioritisation of risk genes for anorexia nervosa https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:53844 Fri 19 Jan 2024 10:17:45 AEDT ]]> Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51745 Fri 15 Sep 2023 18:22:09 AEST ]]> Exploring opportunities for drug repurposing and precision medicine in cannabis use disorder using genetics https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51705 Fri 15 Sep 2023 14:03:12 AEST ]]> The genetic architecture of pneumonia susceptibility implicates mucin biology and a relationship with psychiatric illness https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:51343 Fri 01 Sep 2023 13:34:03 AEST ]]>